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what you need to know about Avanafil Avanafil is a medication primarily used to treat erectile dysfunction (ED), a common condition affecting men worldwide. As one of the phosphodiesterase type 5 (PDE5) inhibitors, Avanafil belongs to the same class of drugs as sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra). Approved by the U.S. Food